Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Comparison of miRNA profile of activated T cells to naive T cells

ABSTRACT: T cells were activated for 1, 3 or 10 days using plate-bound anti-TCR and anti-CD28. Low molecular weight RNA from conventional T cells and activated T cells was hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell state analysis Five arrays, with T cells having been activated for varying lengths of time, including dye swaps.

ORGANISM(S): Mus musculus

SUBMITTER: Bradley Cobb 

PROVIDER: E-GEOD-6006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer  ...[more]

Similar Datasets

Genomics Comparison of miRNA profile of activated T cells to naive T cells
2006-10-26 | GSE6006 | GEO
Proteomics Human naive T-cell secretome, activated and non-activated
2020-10-30 | MSV000086390 | MassIVE
Proteomics Human naive T-cell secretome, activated and non-activated
2018-10-26 | PXD005656 | Pride
Proteomics Proteome of CD4 T cells activated through the TCR in the presence of IL2 and IL12 - Part 1
2019-03-29 | PXD012052 | Pride
Genomics Mint-ChIP-seq from activated CD4 positive, naive alpha-beta T cell (ENCSR767FNB)
2021-06-15 | GSE177666 | GEO
Genomics Mint-ChIP-seq from activated CD4 positive, naive alpha-beta T cell (ENCSR845GYI)
2021-06-15 | GSE177926 | GEO
Genomics Mint-ChIP-seq from activated CD4 positive, naive alpha-beta T cell (ENCSR865YWD)
2021-06-15 | GSE177991 | GEO
Genomics Mint-ChIP-seq from activated CD8-positive, naive alpha-beta T cell (ENCSR012DUX)
2021-11-04 | GSE187109 | GEO
Genomics Mint-ChIP-seq from activated CD8-positive, naive alpha-beta T cell (ENCSR260TLP)
2021-11-04 | GSE187215 | GEO
Genomics Control Mint-ChIP-seq from activated CD4 positive, naive alpha-beta T cell (ENCSR053AWV)
2021-06-15 | GSE176797 | GEO