Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Characterization of the coding and noncoding transcriptome in undifferentiated and differentiating mouse embryonic stem cells

ABSTRACT: RNA (poly(A)+ fraction) has ben isolated from undifferentiated mouse embryonic stem cells and from embryonic stem cells induced to differentiate using the hanging drop model, 6 days following iinduction of differentiation. Profiling of the transcritome at these two stages of differentiation using deep RNA sequencing allows identifying modulated coding and noncoding transcripts upon induction of differentiation. RNA profiling of mouse embryonic stem cells at two stages of differentiation, i.e. undifferntiated state and at day 6 after induction of differentiation. Two conditions, three biological replicates per condition

ORGANISM(S): Mus musculus

SUBMITTER: Frederic Burdet 

PROVIDER: E-GEOD-60097 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The key information processing units within gene regulatory networks are enhancers. Enhancer activity is associated with the production of tissue-specific noncoding RNAs, yet the existence of such transcripts during cardiac development has not been established. Using an integrated genomic approach, we demonstrate that fetal cardiac enhancers generate long noncoding RNAs (lncRNAs) during cardiac differentiation and morphogenesis. Enhancer expression correlates with the emergence of active enhance  ...[more]

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