Transcription profiling of human quadriceps muscle of young Duchenne muscular dystrophy patients and age matched controls

ABSTRACT: Albeit increased serum CK level and abnormal muscle histology are always present, boys with DMD are phenotipically indistinguishable from the normal ones at birth and, in their first years of life, acquire early motor milestones at normal times. A clear defect in muscle function becomes generally apparent by the end of the second year. As the disease is typically diagnosed between the ages of 3 and 7, the first two years are often considered and referred to as clinically presymptomatic. As a defined gene expression signature was shown to characterize these symptomatic patients we sought to investigate whether and to which extent alterations may be also present in muscle from presymptomatic DMD infants. To this aim, we used the Affymetrix technology to compare the individual expression prof

ORGANISM(S): Homo sapiens

SUBMITTER: Mario Pescatori 

PROVIDER: E-GEOD-6011 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress