Examination of gene expression in response to ING2 knockdown by siRNA in human breast cancer cells

ABSTRACT: The Sin3/HDAC multi-protein complex consists of at least 17 subunits and is known to have roles in diverse biological and cellular processes including transcription, chromatin structure, and the cell cycle. ING2 is a non-catalytic component of this complex. To obtain a better mechanistic understanding of the Sin3/HDAC complex in cancer, we extended its protein-protein interaction network and identified a mutually exclusive pair within the complex. Suberoylanilide hydroxamic acid (SAHA) is an FDA approved HDAC inhibitor used for the treatment of cutaneous T-cell lymphoma. We assessed the effects of SAHA on the disruption of the complex network through six homologous baits. SAHA perturbs multiple protein interactions and therefore compromises the composition of large parts of the Sin3/HDAC n

ORGANISM(S): Homo sapiens

SUBMITTER: Chris Seidel 

PROVIDER: E-GEOD-60123 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress