MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes

ABSTRACT: Brown adipose tissue is specialized to burn lipids for heat generation as a natural defense against cold and obesity. Previous studies established microRNAs as essential regulators of brown adipocyte differentiation, but it remains unknown whether microRNAs are required for the feature maintenance of mature brown adipocytes. To address this question, we ablated Dgcr8, a key regulator of the microRNA biogenesis pathway, in mature brown as well as white adipocytes. The adipose tissue -specific Dgcr8 knockout mice displayed enlarged but pale interscapular brown fat with decreased expression of genes characteristic of brown fat, and the mice were intolerant to cold exposure. In vitro primary brown adipocyte cultures confirmed that microRNAs are required for marker gene expression in mature bro

ORGANISM(S): Mus musculus

SUBMITTER: Lei Sun 

PROVIDER: E-GEOD-60165 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress