Unknown,Transcriptomics,Genomics,Proteomics

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Inhalation exposure of hexanal in rats (miRNA)

ABSTRACT: To further development of insight into the mechanism of toxicity, it is important to employ whole genome microarray expression profiling to identify and characterize miRNAs profiles as a discovery platform relevant for toxicologic mechanisms of hexanal. miRNAs have prominent role in cell cycle control, apoptosis, cancer development and proliferation-related processes. However, few reports have described the effect of hexanal on miRNA expression profiles using animal model. In this respect, we studied the expression profiles of miRNAs in hexanal-exposed in rats by miRNA microarray analysis. To evaluate the miRNA expression in lung tissue of rats after exposure of hexanal, Fischer-344 rats were inhaled to three concentrations (600, 1000, 1500 mg/m3) for 5 weeks. miRNA expression analysis was conducted using Rat miRNA 8 x 15K microarray v19.0 (Agilent Technologies, USA).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Yoon Cho

PROVIDER: E-GEOD-60203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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