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Effects of dPRP (PRL8a2) on gene expression of decidual-placental-embryonic tissue

ABSTRACT: DPRP (PRL8a2) is critically involved in adaptations of the placentation site to physiological stressors. DPRP (PRL8a2) restrains the expression of genes associated with ER stress. We used DNA microarrays to analyze the transcriptome of wild type and dPRP null mouse decidual-placental-embryonic tissues from gestation day 7.5.

ORGANISM(S): Mus musculus

SUBMITTER: Michael Soares

PROVIDER: E-GEOD-60220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of dPRP (PRL8a2) on gene expression of decidual-placental-embryonic tissue

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2017-12-19 | E-MTAB-5890 | biostudies-arrayexpress

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Project description:We used full genome microarrays to profile the full lifetime of the mouse placenta from embryonic day 8.5 (e8.5), at the time of chorioallantoic fusion, until postnatal day 0 (P0). For these samples, at each stage the fetal placenta and maternal decidual tissues were dissected and profiled separately (See series 1). For this experiment (Series 2), placental and decidual timecourse samples were normalized and modeled with two undissected (including placental and decidual tissue) e17 placentas to allow for scaling of values for comparison to the undissected placenta samples used in the publicly available mouse GeneAtlas dataset Keywords: time course

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