Telomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)

ABSTRACT: Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors sustain elevated MYC activity in tumours . Here, we identify TERT, the catalytic subunit of telomerase, as a novel regulator of MYC stability in cancers. Binding of TERT to MYC stabilizes its levels on chromatin, contributing to either activation or repression of its target genes. Mechanistically, TERT regulates MYC ubiquitination and stability, and this effect of TERT is independent of its role on telomeres. Genetic inhibition and knocking out of TERT phenocopied the loss of MYC, resulting in

ORGANISM(S): Mus musculus

SUBMITTER: Julius Müller 

PROVIDER: E-GEOD-60223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress