Differentially regulated circulating microRNAs in post-menopausal women suffering from osteoporotic femoral-neck fractures

ABSTRACT: Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level are known to take part in the control of bone formation and bone resorption. Recently, targeted secretion of miRNAs from cells originating from various tissues has been described, which allows for their minimal-invasive detection in serum/plasma and use as biomarkers for presence and progression of pathological conditions. One pilot study has reported circulating miRNAs in serum and tissue of fracture patients. However, further studies are required to explore whether a dysbalance in bone homeostasis of fracture patients can reliably be reflected by specific circu

ORGANISM(S): Homo sapiens

SUBMITTER: Matthias Hackl 

PROVIDER: E-GEOD-60230 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress