Enhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-recruitment and in situ assembly of a large 1-2MDa complex of diverse DNA-binding transcription factors by ERα at ERE-containing enhancers. We refer to enhancers recruiting these factors as mega transcription factor-bound in trans (MegaTrans) enhancers. The MegaTrans complex is a signature of the most potent functional enhancers and is required for activation of enhancer RNA transcription and recruitment of coactivators, including p300

ORGANISM(S): Homo sapiens

SUBMITTER: Daria Merkurjev 

PROVIDER: E-GEOD-60272 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress