Combinatorial cis-regulation in Saccharomyces species

ABSTRACT: Transcriptional control of gene expression is a result of complex interactions between the cis-regulatory elements (CRE) at gene promoters. To understand the regulatory logic of a cell, we need to identify the CRE combinations that regulate gene expression. We developed a sensitive computational method to identify phylogenetically conserved CRE combinations for any species of interest. In contrast to previous methods, we do not need to align genomes to identify these combinations. We applied the method in 7 sensu stricto and sensu lato Saccharomyces species. 80% of the predictions displayed some evidence of combinatorial transcriptional behavior in several existing datasets including 1) ChIP-chip data for co-localization of transcription factors, 2) gene expression data for co-express

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Aaron Spivak 

PROVIDER: E-GEOD-60281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress