Transcription profiling of human cord blood-derived mesenchymal stem cells with distinct growth kinetics, differentiation potentials

ABSTRACT: Phenotypic heterogeneity has been observed among mesenchymal stem/stromal cell (MSC) populations, but specific genes associated with this variability have not been defined. To study this question, we analyzed two distinct MSC populations isolated from the same umbilical cord blood (UCB) sample. These populations (UCB1 and UCB2) are from a single donor, minimizing differences contributed by genetic background. We characterized these UCB-MSCs for cell morphology, growth kinetics, immunophenotype and differentiation potential. UCB1 displayed rapid growth kinetics, higher population doublings, and increased adipogenic lineage differentiation compared to UCB2. To identify the MSC-specific and developmental genes associated with these phenotypic differences, we performed expression analysis u

ORGANISM(S): Homo sapiens

SUBMITTER: Kenro Kusumi 

PROVIDER: E-GEOD-6029 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress