Genome-wide analysis of stress-exposure-associated and exposure-related individual differences associated hippocampus gene expression in males and females.

ABSTRACT: Delineating the molecular basis of individual differences in the stress response is critical to understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In this study, 7 d after predator-scent-stress (PSS) exposure, male and female rats were classified into vulnerable (i.e., M-bM-^@M-^\PTSD-likeM-bM-^@M-^]) and resilient (i.e.,minimally affected) phenotypes on the basis of their performance on a variety of behavioral measures. Genome-wide expression profiling in blood and two limbic brain regions (amygdala and hippocampus), followed by quantitative PCR validation, was performed in these two groups of animals, as well as in an unexposed control group. Differentially expressed genes were identified in blood and brain associated with PSS-exposure and with disti

ORGANISM(S): Rattus norvegicus

SUBMITTER: Nikolaos Daskalakis 

PROVIDER: E-GEOD-60303 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress