Metabolic reprogramming of triple-negative breast cancer and melanoma cell lines by the Let-7a microRNA

ABSTRACT: Let-7 microRNAs (miRNAs) are a family of highly conserved well-established promoters of terminal differentiation that are expressed in all healthy adult tissues and frequently repressed in cancer cells. The tumour suppressive role of let-7 in a variety of cancers in vitro and in vivo has been widely documented and prompted these miRNAs to be candidate genes for miRNA replacement therapy. Reprogrammed metabolism, recently identified as a new hallmark of cancer, contributes to cancer cell growth, proliferation, invasiveness and drug resistance. In this study we identified a new metabolic role of let-7a in triple-negative breast cancer and metastatic melanoma cell lines. We show that let-7a down-regulates key anabolic enzymes, promotes oxidative phosphorylation and mitochondrial ROS formation

ORGANISM(S): Homo sapiens

SUBMITTER: Leonardo Meza-Zepeda 

PROVIDER: E-GEOD-60326 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress