Transcription profiling of four human Adult T-cell leukemia (ATL) cell lines treated with proteasome inhibitor, bortezomib

ABSTRACT: Adult T-cell leukemia (ATL) is a fatal neoplasia derived from HTLV-1 infected T lymphocytes exhibiting constitutive activation of NF-kB. To elucidate the complex molecular mechanism of anti-tumor effect of the proteasome inhibitor, bortezomib in ATL cells, we attempted to perform gene expression profiling. Experiment Overall Design: Four ATL cell lines were cultured with or without bortezomib, then analysed.

ORGANISM(S): Homo sapiens

SUBMITTER: Junko Ohyashiki 

PROVIDER: E-GEOD-6034 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress