Human oocytes reprogram adult somatic cells to pluripotent stem cells [Illumina]

ABSTRACT: The stem cell lines were generated according to the principle described in Noggle et al., Nature 2011, Oct 5;478(7367):70-5. doi: 10.1038/nature10397. Title: Human oocytes reprogram somatic cells to a pluripotent state. Abstract: The exchange of the oocyte's genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cells affected in degenerative human diseases. Such cells, carrying the patient's genome, might be useful for cell replacement. Here we report that the development of human oocytes after genome exchange arrests at late cleavage stages in association with transcriptional abnormalities. In contrast, if the oocyte genome is not removed and the somatic cell genome is merely added, the resultant triploid

ORGANISM(S): Homo sapiens

SUBMITTER: Dieter Egli 

PROVIDER: E-GEOD-60360 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress