CXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia

ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by infiltration of the bone marrow and other sites with transformed T cell progenitors. The role of tissue microenvironments in the pathogenesis of T-ALL or any other type of acute leukemia is little understood. In delineating interactions between T-ALL cells and their environment, we initially found that T-ALL cells express high surface levels of the chemokine receptor CXCR4. Intravital imaging of an intact tibia revealed T-ALL cells in direct contact with bone marrow stromal cells producing the CXCR4 ligand, CXCL12. Genetic targeting of CXCR4 on T-ALL cells resulted in a marked reduction of leukemia burden and prolonged disease remission, and disruption of the CXCL12/CXCR4 axis using small

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Trimarchi 

PROVIDER: E-GEOD-60367 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress