Role of Capicua in metabolic system

ABSTRACT: CIC is a HMG box-containing transcriptional repressor evolutionarily conserved from C. elegans to human. It's known to associate with various types of cancer but physiological function of CIC remain largely unknown. In this study, we characterized Cic hypomorphic (Cic-L-/-) mice and identified critical roles for of CIC in drug metabolism and bile acid homeostasis. Total RNA obtained from isolated liver tissue of Cic-L-/- mouse compared to liver tissue of normal mouse

ORGANISM(S): Mus musculus

SUBMITTER: Jieon Lee 

PROVIDER: E-GEOD-60375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress