Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression

ABSTRACT: Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and lncRNAs in nasopharyngeal carcinoma (NPC) remain unclear. The aim of this study was to investigate the regulatory roles of the TP53 gene in regulating lncRNA and mRNA expression profiles in NPC cell line HNE2. p53 induced gene expression in human nasopharyngeal carcinoma cell line HNE2 was measured at 0, 12, 24 and 48 hours after transfected by pCMV-p53 plasmid.

ORGANISM(S): Homo sapiens

SUBMITTER: Wei Xiong 

PROVIDER: E-GEOD-60379 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2.

Gong Zhaojian Z   Zhang Shanshan S   Zeng Zhaoyang Z   Wu Hanjiang H   Yang Qian Q   Xiong Fang F   Shi Lei L   Yang Jianbo J   Zhang Wenling W   Zhou Yanhong Y   Zeng Yong Y   Li Xiayu X   Xiang Bo B   Peng Shuping S   Zhou Ming M   Li Xiaoling X   Tan Ming M   Li Yong Y   Xiong Wei W   Li Guiyuan G  

PloS one 20141125 11

Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, and post-transcriptional levels. Long non-coding RNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and these RNAs in nasopharyngeal carcinoma remains unclear. The aims of this study were to investigate the regulatory roles o  ...[more]

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