Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage

ABSTRACT: Steroid and xenobiotic receptor (SXR) and its murine ortholog pregnane X receptor (PXR) are nuclear receptors that are expressed mainly in the liver and the intestine. They function as xenobiotic sensors by inducing genes involved in detoxification and drug excretion. Recent evidence showed that SXR and PXR are also expressed in bone tissue where they mediate bone metabolism. Here we report that systemic deletion of PXR results in aging-dependent wearing of articular cartilage of knee joints. Histomorphometrical analysis showed remarkable reduction of width and an enlarged gap between femoral and tibial articular cartilage in PXR knockout mice. We hypothesized that genes induced by SXR in chondrocytes have a protective effect on articular cartilage and identified Fam20a (family with sequen

ORGANISM(S): Mus musculus

SUBMITTER: Kotaro Azuma 

PROVIDER: E-GEOD-60401 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress