DMRT6 coordinates the transition between mitotic and meiotic developmental programs during mamalian spermatogenesis

ABSTRACT: In mammals, a key transition in spermatogenesis is the exit from spermatogonial differentiation and mitotic proliferation and the entry into spermatocyte differentiation and meiosis. Although several genes that regulate this transition have been identified, how it is controlled and coordinated remains poorly understood. Here we examine the role in male gametogenesis of the Doublesex-related gene Dmrt6 (Dmrtb1) and find that Dmrt6 plays a critical role in directing germ cells through the mitotic to meiotic germ cell transition. DMRT6 protein is expressed in late mitotic spermatogonia. In mice of the C57BL/6J strain a null mutation in Dmrt6 disrupts spermatogonial differentiation, causing expression in inappropriate cell types of spermatogonial differentiation factors including SOHLH1, SOHLH

ORGANISM(S): Mus musculus

SUBMITTER: Micah Gearhart 

PROVIDER: E-GEOD-60440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress