Ebf2 is a selective marker of brown and beige adipogenic precursor cells (Microarray)

ABSTRACT: Brown adipocytes, muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic precursor activity in embryos was confined to Pdgfrα+, Myf5Cre-lineage-marked cells. RNAseq analysis identified Early B Cell Factor-2 (Ebf2) as one of the most selectively expressed genes in this cell fraction. Importantly, Ebf2-expressing cells purified from Ebf2-GFP embryos or brown fat tissue did not express myoblast or dermal cell markers and uniformly differentiated into brown adipocytes. Interestingly, Ebf2-expressing cells from white fat tissue in adult animals differentiated into brown-l

ORGANISM(S): Mus musculus

SUBMITTER: Hee-Woong Lim 

PROVIDER: E-GEOD-60442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress