Transcription profiling of human primary lymphomas of the central nervous system suggests PCNSL to be derived from a late germinal center B cell.

ABSTRACT: To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSL of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B cell lymphomas (DLBCL), and (iii) to be in part assigned to the activated B cell-like (ABC) or the germinal center B cell-like (GCB) subtype of DLBCL. Experiment Overall Design: Total RNA was extracted from tissue blocks containing > 80% tumor cells using the TRIzol reagent (Invitrogen, Carlsbad, CA) and pu

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Montesinos-Rongen 

PROVIDER: E-GEOD-6047 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress