Whole genome transcriptome analysis of tumor-specific CD8 T cells in pre-malignant lesions

ABSTRACT: Gene expression analysis of tumor-specific CD8 T cells encountering a tumor-specific antigen in pre-malignant lesions in the liver at different time points post tumor initiation. The overall goal of this mouse study was to elucidate the molecular program in tumor-specific T cells encountering a tumor-specific antigen in pre-malignant lesions. The study identifies the genes and pathways that are dysregulated in tumor-specific T cells associated with T cell unresponsiveness in tumors. To identify the genes and pathways that are dysregulated in tumor-specific T cells. Gene signatures of the following sample groups were compared: 1. Naïve CD8 T cells; 2. Effector CD8 T cells; 3. Dysfunctional tumor-specific CD8 T cells isolated from pre-malignant lesions 8-12 days after tumor induction. 4. D

ORGANISM(S): Mus musculus

SUBMITTER: Andrea Schietinger 

PROVIDER: E-GEOD-60501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress