Gene expression profiling of 18 hepatocellular carcinoma and adjacent non-tumorous liver tissue

ABSTRACT: These paired HCC and non-tumorous liver tissues were used to determine highly differentially expressed genes in HCC and non-tumorous liver tissue. Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. Genes showing extreme differential expression between paired human HCC and adjacent non-tumorous liver tissue were investigated. PLVAP was identified as a gene specifically expressed in vascular endothelial cells of HCC but not in non-tumorous liver tissues. This finding was confirmed by RT-PCR analysis of micro-dissected cells and immunohistochemical staining of tissue sections. A recombinant monoclonal anti-PLVAP Fab fragment co-expressing extracellular domain of human tissue factor (TF) was developed. The potential therapeutic effect and toxicity to treat HCC were stud

ORGANISM(S): Homo sapiens

SUBMITTER: K Kao 

PROVIDER: E-GEOD-60502 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress