Transcription profiling of human circulating monocytes from patients with familial hypercholesterolemia

ABSTRACT: Atherosclerosis is the major cause of death in industrialized countries. This disease has initially been characterized as a lipid disorder, but current concepts argue for an inflammatory disease, which develops in the background of hypercholesterolemia and other risk factors. In response to initial events of atherosclerosis formation, such as LDL-deposition in the subendothelial space, monocytes and T cells interact with the vessel wall. However, little is known about the properties and the behavior of these cells in this context. Using familial hypercholesterolemia (FH) as a model we demonstrate substantial differences in the gene expression of freshly isolated human monocytes and T lymphocytes. In FH monocytes we found an increased uptake of oxidized LDL, elevated amounts of scavenger re

ORGANISM(S): Homo sapiens

SUBMITTER: Sandy Mosig 

PROVIDER: E-GEOD-6054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress