Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Janis Weis
PROVIDER: E-GEOD-6055 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of immunology (Baltimore, Md. : 1950) 20061201 11
The murine model of Lyme disease provides a unique opportunity to study the localized host response to similar stimulus, Borrelia burgdorferi, in the joints of mice destined to develop severe arthritis (C3H) or mild disease (C57BL/6). Pathways associated with the response to infection and the development of Lyme arthritis were identified by global gene expression patterns using oligonucleotide microarrays. A robust induction of IFN-responsive genes was observed in severely arthritic C3H mice at ...[more]