Heritable variation of mRNA decay rates in yeast

ABSTRACT: Gene expression levels are determined by the balance between rates of mRNA transcription and decay, and genetic variation in either of these processes can result in heritable differences in transcript abundance. Although the genetics of gene expression has been the subject of intense interest, the contribution of heritable variation in mRNA decay rates to gene expression variation has received far less attention. To this end, we developed a novel statistical framework and measured allele-specific differences in mRNA decay rates in a diploid yeast hybrid created by mating two genetically diverse parental strains. In total, we estimate that 31% of genes exhibit allelic differences in mRNA decay rate, of which 350 can be identified at a false discovery rate of 10%. Genes with significant alle

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Joshua Akey 

PROVIDER: E-GEOD-60617 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress