Reduction of DNA methylation suppresses colon carcinogenesis through induction of tumor cell differentiation

ABSTRACT: In this study, we analyzed global gene expressions of colon tumors from DNA hypomethylated and the control mice. We found that DNA hypomethylated tumors express significantly higher levels of intestinal differentiation-related genes when compared with the control tumors. These results suggest that DNA methylation may play a role in the maintenance of undifferentiated state of colon tumor cells. Two different Dnmt1 mutant alleles were used in this study; hypomorphic Dnmt1chip allele and conventional KO Dnmt1c allele, which described previously. Previous studies indicated that Dnmt1chip/c mice have reduced DNA methylation contents at pericentromeric satellite repeats, while Dnmt1chip/+ mice have the same levels of genomic methylation as wildtype mice. Experimental mice in an isogenic F1 hybr

ORGANISM(S): Mus musculus

SUBMITTER: Yasuhiro Yamada 

PROVIDER: E-GEOD-60620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress