MiR-155-5p regulates immune cell recruitment to the fetal lung after choriodecidual Group B Streptococcal infection

ABSTRACT: Mechanisms underlying in utero fetal lung injury remain poorly defined, and a greater understanding of pathways regulating these processes may lead to novel therapies that prevent lung injury before birth. MicroRNAs (miRNAs) are small non-coding, endogenous RNAs that regulate gene expression and have been implicated in the pathogenesis of lung disease. We sought to determine whether differentially expressed miRNAs in the fetal lung following choriodecidual infection are associated with elevation of amniotic fluid (AF) cytokine levels and acute lung injury in a nonhuman primate model. After inoculating ten chronically catheterized pregnant monkeys (Macaca nemestrina) at 118-125 days gestation (term=172 days) with either Group B Streptococcus (GBS) 1 x 106 colony forming units (n=5) or salin

ORGANISM(S): Macaca nemestrina

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-60628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress