Humanized Foxp2 Accelerates Making Transitions From Declarative to Procedural Learning

ABSTRACT: Purpose: Foxp2 is the first and for now the only gene connected to speech and language in humans. Two aminoacid substitutions took place in this protein during recent human evolution, after our split from the last common ancestor with chimpanzees, and are most likely to have undergone positive selection in human lineage (Enard et al., 2002). Methods: Transgenic mice in which the wild-type (murine) version of Foxp2 was replaced with the one bearing two human-specific amino acid substitutions (i.e. "humanized" Foxp2) - Foxp2hum/hum, have been compared to their wild-type (WT) counterparts in terms of behavior, electrophysiology and striatal gene expression. The latter was analyzed through RNA-sequencing performed on pooled indexed libraries on three flow cells on Illumina GAIIx. Th

ORGANISM(S): Mus musculus

SUBMITTER: Cemil Kerimoglu 

PROVIDER: E-GEOD-60659 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress