Effect of Helicobacter pylori on ATM-dependent DNA damage responses [cell lines]

ABSTRACT: Carcinogenic bacteria, Helicobacter pylori, induce DNA double-strand breaks in infected host cells. Therefore, we have investigated which genes are upregulated after the infection. Although Helicobacter pylori infection is etiologically related to the inflammation-related malignancy, gastric cancers, it role in the molecular pathogenesis of disease remains unclear. In vitro studies have suggested the infection may cause breaks in double-stranded DNA. We used microarray analysis of H. pylori-infected human gastric biopsies to investigate the effect of H. pylori on gene expression genes involved in DNA repair and DNA damage response. Micro-array analysis and immunohistochemistory showed that ATM (ataxia-telangiectasia mutated) was upregulated in H. pylori gastritis but down regulated in the

ORGANISM(S): Homo sapiens

SUBMITTER: Katsuhiro Hanada 

PROVIDER: E-GEOD-60661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress