Effect of Helicobacter pylori on ATM-dependent DNA damage responses [biopsy]

ABSTRACT: Carcinogenic bacteria, Helicobacter pylori, induce DNA double-strand breaks in infected host cells, while ATM-dependent DNA damage responses in host cells suppress genome instabilities caused by DNA breakages, which resulting in the suppression of H. pylori-induced gastric cancers. Although Helicobacter pylori infection is etiologically related to the inflammation-related malignancy, gastric cancers, it role in the molecular pathogenesis of disease remains unclear. In vitro studies have suggested the infection may cause breaks in double-stranded DNA. We used microarray analysis of H. pylori-infected human gastric biopsies to investigate the effect of H. pylori on gene expression genes involved in DNA repair and DNA damage response. Micro-array analysis and immunohistochemistory showed that

ORGANISM(S): Homo sapiens

SUBMITTER: Katsuhiro Hanada 

PROVIDER: E-GEOD-60662 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress