Sharp changes in gene expression levels along germinal layers distinguish the development of gyrencephaly

ABSTRACT: Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this unique patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, comparing between regions prospective of fold and fissure. We find unique transcriptional signatures in each germinal compartment, indicating that thousands of genes are differentially expressed between regions, including ~80% of genes mutated in human cortical malformations. Regional differences result from sharp changes in gene expression levels, which occur at multiple locations across the developing cortex of ferret and human, but not in the lissencephalic mouse. These complex expression patt

ORGANISM(S): Mustela putorius furo

SUBMITTER: Victor Borrell 

PROVIDER: E-GEOD-60687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress