Epigenetic signatures of alcohol abuse and hepatitis infection during hepatocarcinogenesis

ABSTRACT: Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. Altered DNA methylation landscapes are ubiquitous features of cancer. Interpretation of epigenetic aberrations in HCC is confounded by effects of multiple etiologic drivers and underlying cirrhosis in most cases. We globally profiled the DNA methylome of 34 normal livers and 122 primary liver disease tissues arising in the setting of chronic hepatitis B (HBV) or C (HCV) viral infection, alcoholism (EtOH), and other causes to examine how these environmental agents impact DNA methylation in a manner that contributes to liver disease. Our results demonstrate that each etiologic factor leaves unique and overlapping signatures on the DNA methylome. CpGs aberrantly methylated in cirrhosis-HCV and conserved

ORGANISM(S): Homo sapiens

SUBMITTER: Keith Robertson 

PROVIDER: E-GEOD-60753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress