Transcription profiling of mouse nmyc misexpression in lung (gain of function)

ABSTRACT: Understanding how lung progenitor cells balance; proliferation against differentiation is relevant to clinical; disorders such as bronchopulmonary dysplasia of; premature babies and lung cancer. Previous studies have; established that lung development is severely disrupted in; mouse mutants with reduced levels of the proto-oncogene; Nmyc, but the precise mechanisms involved have not been; explored. We show here that Nmyc expression in the; embryonic lung is normally restricted to a distal population; of undifferentiated epithelial cells, a high proportion of; which are in the S phase of the cell cycle. Overexpression; of NmycEGFP in the epithelium under the control of; surfactant protein C (Sftpc) regulatory elements expands; the domain of S phase cells and upregulates numerous; genes asso

ORGANISM(S): Mus musculus

SUBMITTER: Brian Joseph Cox 

PROVIDER: E-GEOD-6077 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress