Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Drosophila Larval Brain RNA sequencing of ablation versus activation of E347 neurons

ABSTRACT: RNA sequencing data for replicates of E347 driver control, E347 neuronal ablation per Shi dominant-negative expression and activation per NachBac expression to identify differences in RNA abundancy E347 driver control, E347 neuronal ablation per Shi dominant-negative expression and activation per NachBac expression

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jay Hesselberth

PROVIDER: E-GEOD-60822 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat.

Mosher Jeremy J Zhang Wei W Blumhagen Rachel Z RZ D'Alessandro Angelo A Nemkov Travis T Hansen Kirk C KC Hesselberth Jay R JR Reis Tânia T

Developmental biology 20150721 2

The brain plays a critical yet incompletely understood role in regulating organismal fat. We performed a neuronal silencing screen in Drosophila larvae to identify brain regions required to maintain proper levels of organismal fat. When used to modulate synaptic activity in specific brain regions, the enhancer-trap driver line E347 elevated fat upon neuronal silencing, and decreased fat upon neuronal activation. Unbiased sequencing revealed that Arc1 mRNA levels increase upon E347 activation. We ...[more]

PMID: 26209258

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Dataset Information

Drosophila Larval Brain RNA sequencing of ablation versus activation of E347 neurons

Publications

Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat.

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