Regulatory RNA Apela Is a Component of a Negative Feedback Loop Regulating p53-Mediated Apoptosis in Embryonic Stem Cells (II)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jing Huang
PROVIDER: E-GEOD-60843 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells.
Li Mangmang M Gou Hongfeng H Tripathi Brajendra K BK Huang Jing J Jiang Shunlin S Dubois Wendy W Waybright Tim T Lei Ming M Shi Jianxin J Zhou Ming M Huang Jing J
Cell stem cell 20150430 6
Maintaining genomic integrity is of paramount importance to embryonic stem cells (ESCs), as mutations are readily propagated to daughter cells. ESCs display hypersensitivity to DNA damage-induced apoptosis (DIA) to prevent such propagation, although the molecular mechanisms underlying this apoptotic response are unclear. Here, we report that the regulatory RNA Apela positively regulates p53-mediated DIA. Apela is highly expressed in mouse ESCs and is repressed by p53 activation, and Apela deplet ...[more]
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