Transcription profiling of mouse cytotoxic T lymphocyte cell line CTLL-2 treated with interleukin-2

ABSTRACT: The cytokine IL-2 determines T cell fate by controlling T cell proliferation and differentiation, but the expression files of IL-2 regulated genes are not defined; Using Affymetrix mouse genome array and mouse T cell line CTLL-2, we analyzed the expression profiles of IL-2 regulated genes over 10 time points in 24 hours after IL-2 treatment. A total of 2,813 genes were differentially expressed (>=2-fold change) at least at one time point in response to IL-2 stimulation. Clustering analyses showed that these genes consist of 9 clusters, suggesting that the IL-2 regulated genes in mouse T cells have 9 expression patterns. These genes involve in many biological processes, including immune response, signal transduction, apoptosis, cell cycle, transcription, transport, biosynthesis and various

ORGANISM(S): Mus musculus

SUBMITTER: Zhaoduo Zhang 

PROVIDER: E-GEOD-6085 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress