Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors

ABSTRACT: This study provides an overview of the transcriptional signature of oligodendrocyte progenitor cells (OPCs) exposed to the CSF collected from multiple sclerosis patients with either a relapsing remitting disease course (RRMS) or a confirmed primary progressive diagnosis (PPMS). Using an Affymetrix microarray we were able to detect a set of common and unique genes for each treatment group. Gene ontology analysis revealed a common group of genes involved in protein transport, actin dynamics and response to stress and DNA damage, while the RRMS-specific genes were grouped according to protein complex biogenesis, nuclear transport and RNA processing. The transcriptional signature of progenitors exposed to PPMS was characterized by an up-regulation of the pro-differentiation adhesion molecule

ORGANISM(S): Rattus norvegicus

SUBMITTER: Angela Riffo-Campos 

PROVIDER: E-GEOD-60881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress