Prediction of isolated central nervous system relapses in pediatric acute lymphoblastic leukemia

ABSTRACT: Background In childhood acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is rare at diagnosis (1-4%), but more frequent at relapse (~30%). Minimal residual disease diagnostics predict most bone marrow (BM) relapses, but likely cannot predict isolated CNS relapses. Consequently, CNS relapses may become relatively more important. Because of the significant late sequelae of CNS treatment, early identification of patients at risk of CNS relapse is crucial. Methods Gene expression profiles of ALL cells from cerebrospinal fluid (CSF) and ALL cells from BM were compared and differences were confirmed by real-time quantitative PCR. For a selected set of overexpressed genes, protein expression levels of ALL cells in CSF at relapse and of ALL cells in diagnostic B

ORGANISM(S): Homo sapiens

SUBMITTER: Vincent van der Velden 

PROVIDER: E-GEOD-60926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress