Antagonistic interaction between androgen signaling and vitamin D signaling in prostate cancer [Expression profiling]

ABSTRACT: Vitamin D induces anti-proliferative and differentiating effects in prostate cancer. Thus calcitriol, the hormonally active form of Vitamin D, and its analogs have been extensively studied in prostate cancer cells. Yet despite its importance, relatively little is known about the genome-scale mechanisms by which Vitamin D, through its cognate nuclear vitamin D receptor (VDR), exerts its regulatory functions at the genomic level. In this study, we defined VDR transcriptional networks in the LNCaP prostate cancer cell line by mapping the genomic binding sites of VDR and by identifying differentially expressed genes upon calcitriol treatment. We found that VDR and androgen receptor (AR) antagonistically regulate a subset of cell cycle-related genes that are over-expressed in prostate cancer tu

ORGANISM(S): Homo sapiens

SUBMITTER: Yuwen Liu 

PROVIDER: E-GEOD-60956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress