Integrative Molecular Concepts Modeling of Prostate Cancer Progression

ABSTRACT: Using laser capture microdissection to isolate over 100 specific cell populations, we report the profiling of prostate cancer progression from benign epithelium to metastatic disease. By analyzing these expression signatures in the context of over 15,000 â??molecular conceptsâ??, or sets of biologically connected genes, we generated an integrative model of prostate cancer progression. Keywords: disease state analysis Experiment Design: â?¢ Type of experiment: This study used microarray experiments to profile prostate cancer progression through the isolation of pure cell populations using laser capture microdissection (LCM) and OmniPlex Whole Transcriptome (WTA) Amplification. â?¢ Experimental factors: This study profiled various pure cell populations isolated by LCM from prostate tis

ORGANISM(S): Homo sapiens

SUBMITTER: Arul Chinnaiyan 

PROVIDER: E-GEOD-6099 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress