Long non-coding RNAs are differentially expressed in hepatocellular carcinoma cell lines with different metastatic potential

ABSTRACT: We describe the lncRNA expression profiles of two HCC cell lines, one with high potential for metastasis to the lung (HCCLM3) and the other to lymph nodes (HCCLYM-H2). The HCCLM3(LM3) and HCCLM6 cell lines were derived from the same parental cell line MHCC-97H. LM3 metastasizes to the lung, while HCCLM6 can metastasize to multiple organs in a mouse model. By subcloning HCCLM6, we established the HCCLYM-H2(H2) cell line, which showed stable and high metastatic potential specific to the lymph nodes. In the present study, we compared the expression profiles of HCC cell lines with a similar genetic background but different potential for lung or lymph node metastasis. We found that expression signatures comprising lncRNAs and protein-coding mRNAs were significantly associated with organ-specifi

ORGANISM(S): Homo sapiens

SUBMITTER: Fang Tingting 

PROVIDER: E-GEOD-61015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress