TRANSCRIPTOME MODIFICATIONS IN HUMAN GINGIVAL FIBROBLASTS EXPOSED TO 2-HYDROXYETHYL-METHACRYLATE (HEMA)

ABSTRACT: Objective: 2-Hydroxyethyl methacrylate (HEMA), one of the most common components of tooth filling materials, could diffuse throughout dentine, and in gingival and pulp cells, affecting odontoblast vitality. Design: the aim of this study was to assess the differential transcriptome modulation induced by HEMA treatment in human cultured gingival fibroblasts (HGFs) at different exposure time compared to untreated cells. Materials and methods: Gene expression profile was performed by employing a whole gene microarray approach on RNA extracted from cultured HGFs exposed to 3 mmol/l HEMA for 24 or 96 h. Differentially identified transcripts were analyzed by Ingenuity Pathways Analysis software to disclose genes biological functions. Results: Hierarchical clustering analysis of the data set origi

ORGANISM(S): Homo sapiens

SUBMITTER: Valentina Gatta 

PROVIDER: E-GEOD-61043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress