A genome-wide search for epigenetically regulated genes in zebra finch using MethylCap-seq and RNA-seq

ABSTRACT: DNA methylation is tightly linked with gene expression regulation and has long been regarded a stable epigenetic mark in postmitotic cells. However, it recently became clear that postnatal brains appear to show stimulus-induced de novo CpG methylation or active demethylation related to neuronal plasticity. Due to striking homologies between the brains of birds and mammals, songbirds, especially the zebra finch, propose an attractive model for investigating the genome-wide DNA methylation profile and DNA methylation reconfiguration during brain development. In order to obtain a first genome-wide compendium of genes under putative DNA methylation control, we performed MethyCap-seq experiments on two recently cultured zebra finch cell lines, G266 and ZFTMA, also upon AZA-induced demethylation

ORGANISM(S): Taeniopygia guttata

SUBMITTER: Sandra Steyaert 

PROVIDER: E-GEOD-61060 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress