Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia

ABSTRACT: Intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea (OSA), which has been proposed as the major determinant of processes involving tumor invasion and metastasis. To study whether circulating DNA (cirDNA) in blood plasma reflects the changes that the tumor cells undergo under IH conditions, we used a xenografted murine model. Mice engrafted with TC1 epithelial lung and controls were exposed to IH or room air (RA) conditions. Plasma cirDNA amounts were significantly increased in mice exposed to IH (p<0.05). We found a significant correlation between plasma cirDNA concentration and tumor size, weight and invasiveness (p<0.05). Using a microarray-based approach, we identified 2,094 regions showing significant differential cirDNA modifications. System biology analysis revealed an

ORGANISM(S): Mus musculus

SUBMITTER: Rene Cortese 

PROVIDER: E-GEOD-61070 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress