Comparative genomic hybridization of human gliomas (178)

ABSTRACT: Primary brain tumors are the fourth leading cause of cancer mortality in adults under the age of 54 years and the leading cause of cancer mortality in children in the United States. Therapy for the most common type of primary brain tumors, gliomas, remains suboptimal. The development of new and more effective treatments will likely require a better understanding of the biology of these tumors. Here, we show that use of the high-density 100K single-nucleotide polymorphism arrays in a large number of primary tumor samples allows for a much higher resolution survey of the glioma genome than has been previously reported in any tumor type. We not only confirmed alterations in genomic areas previously reported to be affected in gliomas, but we also refined the location of those sites and uncover

ORGANISM(S): Homo sapiens

SUBMITTER: Howard Fine 

PROVIDER: E-GEOD-6109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress