Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver

ABSTRACT: Overexpression of p21 in NEMOM-NM-^Thepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage. Expression profiling of livers from wild type, NEMO, and NEMO-P21 null mice.

ORGANISM(S): Mus musculus

SUBMITTER: Guido Hooiveld 

PROVIDER: E-GEOD-61100 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress