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Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance and response in castration-resistant prostate cancer

ABSTRACT: aCGH experiment on cell-free DNA collected from the plasma of patients with castration-resistant prostate cancer. No replicates. castration-resistant prostate cancer vs male reference DNA

ORGANISM(S): Homo sapiens

SUBMITTER: Shawn Anderson

PROVIDER: E-GEOD-61134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer.

Azad Arun A AA Volik Stanislav V SV Wyatt Alexander W AW Haegert Anne A Le Bihan Stephane S Bell Robert H RH Anderson Shawn A SA McConeghy Brian B Shukin Robert R Bazov Jenny J Youngren Jack J Paris Pamela P Thomas George G Small Eric J EJ Wang Yuzhuo Y Gleave Martin E ME Collins Colin C CC Chi Kim N KN

Clinical cancer research : an official journal of the American Association for Cancer Research 20150223 10

<h4>Purpose</h4>Although novel agents targeting the androgen-androgen receptor (AR) axis have altered the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC), development of therapeutic resistance is inevitable. In this study, we examined whether AR gene aberrations detectable in circulating cell-free DNA (cfDNA) are associated with resistance to abiraterone acetate and enzalutamide in mCRPC patients.<h4>Experimental design</h4>Plasma was collected from 62 mCRPC patient ...[more]

PMID: 25712683

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